Buy Methylone Crystals is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone.
The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.
Buy Methylone Crystal Online was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant.
Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries.
Resemblance to MDMA
Structural similarities between some amphetamine-like stimulants and their 3,4-methylenedioxy- derivatives.
Left: amphetamine, methamphetamine and methcathinone.
Buy Methylone Crystal Online substitutes for MDMA in rats trained to discriminate MDMA from saline.
Methylone does not substitute for amphetamine or for the hallucinogenic DOM in animals trained to discriminate between these drugs and saline.
Further, also in common with MDMA, methylone acts on monoaminergic systems.
In vitro, Buy Methylone Crystal Online has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.
In spite of these behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical.
Buy Methylone Crystal Online has almost the same potency of MDMA, but it does not produce the same effects.
It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA.”
Buy Methylone Crystal Online acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.
In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar.
Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.
Is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic.
And behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities.
The two major metabolic pathways in mammals for methylone are N-demethylation to methylenedioxycathinone (MDC), and demethylation.
Followed by O-methylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC).
When 5 mg/kg of methylone was administered to rats, it was found that around 26%.
Was excreted as HMMC within the first 48 hours (less than 3% excreted unchanged).
Dosage and Over-Dose of METHYLONE
The dosage of the drug ranges from 75mg to 325mg. Light doses of the drug range from 75mg – 150mg while the commonly administered dose ranges from 150-225mg. A heavy dose of the drug is greater than or equal to 325mg.
The over dose can cause the full range of effects but come with adverse side effects as well which include serious injury or death in severe conditions.
Legal Status of METHYLONE
The production, supply and possession of the drug is controlled in most of the countries due to its misuse. Buy Methylone Crystals Online
Where Can You Buy METHYLONE Crystals Online?
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